frizzled-2; Fz-2; hFz2; FzE2 (FZD2)

Function: - receptor for Wnt proteins - most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin & activation of Wnt target genes - a second signaling pathway involving PKC & Ca⁺² fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase - both pathways seem to involve interactions with G-proteins - may be involved in transduction & intercellular transmission of polarity information during tissue morphogenesis &/or in differentiated tissues Structure: - Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (putative) - FZ domain is involved in binding with Wnt ligands - belongs to the G-protein coupled receptor Fz/smo family - contains 1 FZ (frizzled) domain Compartment: - membrane Expression: - widely expressed - in adults, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas,prostate, testis, ovary & colon - in the fetus, expressed in brain, lung & kidney - low levels in fetal liver

General

frizzled homolog protein glycoprotein

Properties

SIZE: entity length = 565 aa MW = 64 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-247} MOTIF: signal sequence {1-23} frizzled domain {34-153} cysteine residue {C39} MODIFICATION: cysteine residue {C100} cysteine residue {C47} MODIFICATION: cysteine residue {C93} N-glycosylation site {N53} cysteine residue {C84} MODIFICATION: cysteine residue {C121} cysteine residue {C93} MODIFICATION: cysteine residue {C47} cysteine residue {C100} MODIFICATION: cysteine residue {C39} cysteine residue {C110} MODIFICATION: cysteine residue {C150} cysteine residue {C114} MODIFICATION: cysteine residue {C138} cysteine residue {C121} MODIFICATION: cysteine residue {C84} cysteine residue {C138} MODIFICATION: cysteine residue {C114} cysteine residue {C150} MODIFICATION: cysteine residue {C110} N-glycosylation site {N154} glycine-rich region {181-187} transmembrane domain {248-268} cytoplasmic loop {269-279} transmembrane domain {280-300} exoplasmic loop {301-327} transmembrane domain {328-348} cytoplasmic loop {349-370} transmembrane domain {371-391} exoplasmic loop {392-414} transmembrane domain {415-435} cytoplasmic loop {436-461} transmembrane domain {462-482} exoplasmic loop {483-519} transmembrane domain {520-540} cytoplasmic domain {541-565} MOTIF: Lys-Thr-X-X-X-Trp {543-548} PDZ recognition motif NAME: PDZ recognition motif SITE: 563-565 FOR-BINDING-VIA: PDZ domain

Database Correlations

OMIM 600667 UniProt Q14332 PFAM correlations Entrez Gene 2535 Kegg hsa:2535