frizzled-10; Fz-10; hFz10; FzE7; CD350 (FZD10)

Function: - receptor for Wnt proteins - most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin & activation of Wnt target genes - a second signaling pathway involving PKC & Ca⁺² fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase - both pathways seem to involve interactions with G-proteins - may be involved in transduction & intercellular transmission of polarity information during tissue morphogenesis &/or in differentiated tissues Structure: - Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (putative) - FZ domain is involved in binding with Wnt ligands - belongs to the G-protein coupled receptor Fz/smo family - contains 1 FZ (frizzled) domain Compartment: -membrane Expression: - expressed in placenta & fetal kidney > fetal lung & brain - in adult brain, expressed in cerebellum > cerebral cortex, medulla & spinal cord - very low levels in total brain, frontal lobe, temporal lobe & putamen - weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen & prostate

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen frizzled homolog protein glycoprotein

Properties

SIZE: entity length = 581 aa MW = 65 kD COMPARTMENT: plasma membrane MOTIF: signal sequence {1-20} exoplasmic domain {21-225} MOTIF: frizzled domain {29-150} cysteine residue {C34} MODIFICATION: cysteine residue {C95} cysteine residue {C42} MODIFICATION: cysteine residue {C88} N-glycosylation site {N48} cysteine residue {C79} MODIFICATION: cysteine residue {C117} cysteine residue {C88} MODIFICATION: cysteine residue {C42} cysteine residue {C95} MODIFICATION: cysteine residue {C34} cysteine residue {C106} MODIFICATION: cysteine residue {C147} cysteine residue {C110} MODIFICATION: cysteine residue {C134} cysteine residue {C117} MODIFICATION: cysteine residue {C79} cysteine residue {C134} MODIFICATION: cysteine residue {C110} cysteine residue {C147} MODIFICATION: cysteine residue {C106} N-glycosylation site {N153} transmembrane domain {226-246} cytoplasmic loop {247-262} transmembrane domain {263-283} exoplasmic loop {284-311} transmembrane domain {312-332} cytoplasmic loop {333-351} transmembrane domain {352-372} exoplasmic loop {373-393} transmembrane domain {394-414} cytoplasmic loop {415-443} transmembrane domain {444-464} exoplasmic loop {465-502} MOTIF: N-glycosylation site {N485} transmembrane domain {503-523} cytoplasmic domain {524-581} MOTIF: Lys-Thr-X-X-X-Trp {526-531} PDZ recognition motif NAME: PDZ recognition motif SITE: 579-581 FOR-BINDING-VIA: PDZ domain

Database Correlations

OMIM 606147 UniProt Q9ULW2 PFAM correlations Entrez Gene 11211 Kegg hsa:11211