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fringe homolog protein

family of proteins which participate in the formation of boundaries between groups of cells during development. Function: - Fringe proteins have fucose-specific beta 1,3-N-acetylglucos-aminyltransferase activity that catalyzes elongation of O-linked fucose on EGF repeats of Notch, which modulates Notch signaling. - Fringe proteins can positively and negatively modulate the ability of Notch ligands to activate Notch receptors - there are functional differences between various fringes in their ability to modulate different Notch ligand binding to Notch receptors - Fringe beta 1,3-N-acetylglucosaminyltransferase activity is necessary but not sufficient to inhibit jagged 1 protein induced Notch signalling - beta-4-galactosyltransferase-1 is also required [2] Comparative biology: - originally named Drosophila protein; 3 mammalian homologs identified: lunatic fringe, radical fringe & manic fringe

Specific

lunatic fringe; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (LFNG) manic fringe; beta-1,3-N-acetylglucosaminyltransferase manic fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (MFNG) radical fringe; beta-1,3-N-acetylglucosaminyltransferase radical fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (RFNG)

General

glycosyltransferase membrane protein

Properties

COMPARTMENT: cellular membrane MOTIF: membrane region active site

References

  1. Shimizu et al. J Biol Chem 276: 25753-8, 2001.
  2. Chen et al. PNAS 98:13716-21, 2001