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FRAS1-related extracellular matrix protein 3 (FREM3)
Function:
1) extracellular matrix protein
2) role in cell adhesion
3) Calx-beta domains bind Ca+2 with conformational change
Structure:
1) belongs to the FRAS1 family
2) contains 3 Calx-beta domains
- contains 12 CSPG repeats (NG2 repeats)
Compartment: secreted, extracellular matrix
General
Ca+2 binding protein
cell adhesion protein
Properties
SIZE: MW = 238 kD
entity length = 2135 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-30}
CSPG {285-413}
CSPG {414-524}
CSPG {525-683}
CSPG {684-811}
CSPG {812-922}
MOTIF: N-glycosylation site {N846}
CSPG {923-1054}
CSPG {1055-1173}
CSPG {1174-1285}
CSPG {1286-1403}
MOTIF: N-glycosylation site {N1366}
N-glycosylation site {N1372}
CSPG {1404-1515}
CSPG {1516-1633}
MOTIF: N-glycosylation site {N1585}
CSPG {1634-1758}
Calx-beta 1 {1759-1858}
Calx-beta 2 {1871-1981}
Calx-beta 3 {1996-2102}
Database Correlations
OMIM 608946
UniProt P0C091
Pfam PF03160
References
UniProt :accession P0C091