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Fractalkine; C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; neurotactin; small-inducible cytokine D1 (CX3CL1, FKN, NTT, SCYD1, NKAF, A-152E52)
Function:
- the soluble form is chemotactic for T-cells & monocytes
- the soluble form is not chemotactic for neutrophils
- the membrane-bound form promotes adhesion of T-cells & monocytes to endothelial cells
- may play a role in regulating leukocyte adhesion & migration processes at the endothelium
- binds to CX3CR1
- soluble short 95 kD form may be released by proteolytic cleavage from the long membrane-anchored form
Structure:
- monomer
- O-glycosylated with core 1 glycan or possibly core 8 glycan
- belongs to the intercrine delta family
Compartment:
- cell membrane; single-pass type 1 membrane protein
- exists as membrane protein & secreted form
Expression:
- expressed in small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney & pancreas
- induced by TNF & IL-1 in pulmonary endothelial cells & umbilical vein endothelial cells
Interactions
molecular events
General
CX3C or CXXXC chemokine
membrane protein
Properties
SIZE: entity length = 397 aa
MW = 42 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-24}
Chemokine {25-100}
MOTIF: cysteine residue {C32}
MODIFICATION: cysteine residue {C58}
N-glycosylation site {N33}
cysteine residue {C36}
MODIFICATION: cysteine residue {C74}
cysteine residue {C58}
MODIFICATION: cysteine residue {C32}
cysteine residue {C74}
MODIFICATION: cysteine residue {C36}
Mucin-like stalk {101-341}
MOTIF: Thr glycosylation site {T183}
Ser glycosylation site {S253}
Thr glycosylation site {T329}
proteolytic site {339-340}
transmembrane domain {342-362}
References
- UniProt :accession P78423
- Wikipedia; Note: CX3CL1 entry
http://en.wikipedia.org/wiki/CX3CL1
Component-of
molecular complex
Databases & Figures
OMIM 601880
UniProt P78423
Pfam PF00048
Entrez Gene 6376
Kegg hsa:6376
XC and CX3C ligand and receptor binding