fra/jun complex

Binds to AP-1 sites.

General

DNA-binding protein transcription factor complex

Properties

COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SUBUNITS: Fos-related antigen 1 MOTIF: glutamate-rich region {103-106} MOTIF: glutamate residue (SEVERAL) DNA-binding motif SITE: 111-129 leucine zipper SITE: 133-161 FOR-BINDING-VIA: leucine zipper basic helix-loop-helix {CBHLH} MOTIF: basic DNA-binding motif helix-loop-helix NAME: helix-loop-helix EFFECTOR-BOUND: c-jun proto-oncogene protein BOUND-VIA: helix-loop-helix FOR-BINDING-VIA: helix-loop-helix FOR-BINDING-OF: DNA motif FOR-BINDING-VIA: helix-loop-helix leucine zipper EFFECTOR-BOUND: c-jun proto-oncogene protein BOUND-VIA: leucine zipper FOR-BINDING-VIA: leucine zipper LEUCINES: 5 serine-rich region {251-255} MOTIF: serine residue (SEVERAL) c-jun proto-oncogene protein MOTIF: Thr phosphorylation site {T2} Thr phosphorylation site {T8} Ser phosphorylation site {S58} Thr phosphorylation site {T62} Ser phosphorylation site {S63} Ser phosphorylation site {S73} Thr phosphorylation site {T89} Thr phosphorylation site {T93} Thr phosphorylation site {T239} Ser phosphorylation site {S243} hinge region basic helix-loop-helix {C-TERMINAL} MOTIF: basic DNA-binding motif MOTIF: cysteine residue {X+1} helix-loop-helix NAME: helix-loop-helix EFFECTOR-BOUND: Fos-related antigen 1 BOUND-VIA: helix-loop-helix FOR-BINDING-VIA: helix-loop-helix FOR-BINDING-OF: DNA motif FOR-BINDING-VIA: helix-loop-helix leucine zipper SITE: C-TERMINAL EFFECTOR-BOUND: Fos-related antigen 1 BOUND-VIA: leucine zipper FOR-BINDING-VIA: leucine zipper LEUCINES: 5 Ser phosphorylation site {S249} DNA-binding motif SITE: 257-276 MOTIF: cysteine residue {269} arginine residue {272} helix-loop-helix NAME: helix-loop-helix FOR-BINDING-VIA: helix-loop-helix leucine zipper SITE: 280-308 FOR-BINDING-VIA: leucine zipper MOTIF: Thr phosphorylation site {T286}

References

Morgan & Curran The Neuroscientist 1:68 1995

Components

c-jun proto-oncogene protein; v-jun avian sarcoma virus 17 oncogene homolog; p39 (JUN) Fos-related antigen 1; FRA-1 (FOSL1, FRA1)