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4 1/2 half LIM domains protein 5 (FHL-5, activator of cAMP-responsive element modulator in testis, activator of CREM in testis)
Function:
1) regulation of spermatogenesis
2) stimulates CREM transcriptional activity (phosphorylation- independent)
3) interacts with CREM via the 3rd LIM domain
Structure:
- contains 4 LIM zinc-binding domains
Compartment: nuclei of round & elongated spermatids
Expression: testis-specific
General
nuclear protein
testis-specific protein
Properties
SIZE: MW = 33 kD
entity length = 284 aa
COMPARTMENT: cell nucleus
MOTIF: Zinc finger
NAME: Zinc finger
SITE: 8-32
EFFECTOR-BOUND: Zn+2
LIM domain {39-100}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {101-160}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {161-220}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {223-283}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
Database Correlations
OMIM 605126
UniProt Q5TD97
Pfam PF00412
References
UniProt :accession Q5TD97