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formin-like protein 1 (leukocyte formin, CLL-associated antigen KW-13, FMNL1, C17orf1, C17orf1B, FMNL)
Function:
1) control of cell motility & survival of macrophages (putative)
2) interacts with RAC1, PFN1 & PFN2
Structure:
1) belongs to the formin homology family
2) contains 1 DAD domain (diaphanous autoregulatory domain)
- contains 1 FH2 domain (formin homology 2 domain)
- contains 1 GBD/FH3 domain (Rho GTPase-binding/formin homology 3 domain)
Compartment: cytoplasm
Alternative splicing: named isoforms=2
Expression:
- expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas
General
formin homology family protein
Properties
SIZE: MW = 122 kD
entity length = 1100 aa
COMPARTMENT: cytoplasm
MOTIF: GBD/FH3 {27-468}
proline-rich region
SITE: 459-616
MOTIF: proline residue (SEVERAL)
FH2 {633-998}
DAD {1059-1090}
Database Correlations
OMIM 604656
UniProt O95466
PFAM correlations
References
UniProt :accession O95466