formin-1 (limb deformity protein homolog, FMN1, FMN, LD)

Function: - role in the formation of adherens junction & polymerization of linear actin cables (putative) - interacts with alpha-catenin & may interact with tubulin (putative) - phosphorylated on Ser & possibly Thr Structure: - belongs to the formin homology family, Cappuccino subfamily - contains 1 FH1 (formin homology 1) domain - contains 1 FH2 (formin homology 2) domain Compartment: - nucleus, cytoplasm cell junction, adherens junction - peripheral membrane, cytoplasmic side (putative) - localization to the adherens junctions is alpha-catenin- dependent - also localizes to F-actin bundles originating from adherens junctions & to microtubules (putative) Alternative splicing: named isoforms=3 Expression: expressed in fetal kidney & fetal lung

General

cytoskeletal protein phosphoprotein

Properties

SIZE: entity length = 1419 aa MW = 158 kD COMPARTMENT: cytoplasm MOTIF: binding site SITE: 1-622 FOR-BINDING-OF: microtubule alpha-catenin interaction {456-842} MOTIF: Ser phosphorylation site {S518} Ser phosphorylation site {S522} coiled coil {720-774} proline-rich region SITE: 869-984 MOTIF: proline residue (SEVERAL) FH1 {870-957} FH2 {973-1363}

Database Correlations

OMIM 136535 UniProt Q68DA7 Pfam PF02181

References

UniProt :accession Q68DA7