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formimidoyltransferase-cyclodeaminase (formiminotransferase-cyclodeaminase, FTCD, LCHC1 [includes: glutamate formimidoyltransferase/glutamate formiminotransferase/glutamate formyltransferase & formimidoyltetrahydrofolate cyclodeaminase/formiminotetrahydrofolate cyclodeaminase])
Function:
1) folate-dependent enzyme
2) displays both transferase & deaminase activity
3) channels one-carbon units from formiminoglutamate to folate pool
4) histidine degradation, 4th & steps
5) may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
Cofactor: pyridoxal phosphate
Structure:
1) homooctamer
2) subunits are arranged as a tetramer of dimers, & form a planar ring-shaped structure
4) polyglutamate binding sites
Compartment: cytoplasm
Alternative splicing: named isoforms=4
Note:
- may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
Pathology:
- defects in FTCD are the cause of formiminoglutamicaciduria
General
enzyme
Properties
SIZE: MW = 59 kD
entity length = 541 aa
COMPARTMENT: cytoplasm
MOTIF: Formiminotransferase {1-236}
MOTIF: histidine residue {H82}
Folate binding (Potential) {163-172}
Database Correlations
OMIM correlations
MORBIDMAP 606806
UniProt O95954
PFAM correlations
ENZYME correlations
References
UniProt :accession O95954