forkhead box protein P4 (FOXP4)

Function: - transcriptional repressor - represses lung-specific expression - forms homodimers & heterodimers with FOXP1 & FOXP2 - dimerization is required for DNA-binding - leucine-zipper is required for dimerization & transcriptional repression Structure: - contains 1 C2H2-type zinc finger - contains 1 fork-head DNA-binding domain Compartment: nucleus

General

C2H2 type zinc finger protein forkhead family transcription factor

Properties

SIZE: MW = 73 kD entity length = 680 aa COMPARTMENT: cell nucleus MOTIF: glutamine-rich region {65-219} MOTIF: glutamine residue (SEVERAL) Zn finger C2H2-type SITE: 307-332 EFFECTOR-BOUND: Zn+2 leucine zipper SITE: 349-370 FOR-BINDING-VIA: leucine zipper fork head domain NAME: fork head domain SITE: 467-559

Database Correlations

UniProt Q8IVH2 PFAM correlations Entrez Gene 116113