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forkhead box protein P3; zinc finger protein JM2; scurfin (FOXP3)

Function: - probable transcription factor - role in control of immune response Structure: - contains 1 C2H2-type zinc finger - contains 1 fork-head DNA-binding domain Compartment: nucleus Alternative splicing: named isoforms=2 Pathology: - defects in FOXP3 are the cause of X-linked autoimmunity-immunodeficiency syndrome

General

C2H2 type zinc finger protein forkhead family transcription factor

Properties

SIZE: MW = 47 kD entity length = 431 aa COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 199-222 EFFECTOR-BOUND: Zn+2 fork head domain NAME: fork head domain SITE: 337-423

Database Correlations

OMIM 300292 MORBIDMAP 300292 UniProt Q9BZS1 Entrez Gene 50943

References

  1. OMIM :accession 300292
  2. Entrez Gene :accession 50943
  3. UniProt :accession Q9BZS1
  4. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=FOXP3
  5. Wikipedia FOXP3 entry http://en.wikipedia.org/wiki/FOXP3