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forkhead box protein P1 (FOXP1)
Function:
- transcriptional repressor
- role in specification & differentiation of lung epithelium
- can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential
- forms homodimers & heterodimers with FOXP2 & FOXP4
- dimerization is required for DNA-binding
- interacts with CTBP1
Structure:
- contains 1 C2H2-type zinc finger
- contains 1 fork-head DNA-binding domain
- leucine-zipper is required for dimerization & transcriptional repression
Compartment: nucleus
Alternative splicing: named isoforms=4
General
C2H2 type zinc finger protein
forkhead family transcription factor
Properties
SIZE: MW = 75 kD
entity length = 677 aa
COMPARTMENT: cell nucleus
MOTIF: glutamine-rich region {55-230}
MOTIF: glutamine residue (SEVERAL)
Zn finger C2H2-type
SITE: 306-331
EFFECTOR-BOUND: Zn+2
leucine zipper
SITE: 348-369
FOR-BINDING-VIA: leucine zipper
binding site
SITE: 382-386
FOR-BINDING-OF: C-terminal-binding protein 1
fork head domain
NAME: fork head domain
SITE: 465-555
Database Correlations
OMIM 605515
UniProt Q9H334
References
- Entrez Gene :accession 27086
- UniProt :accession Q9H334