forkhead box protein M1; forkhead-related protein 16; hepatocyte nuclear factor 3 forkhead homolog 11; M-phase phosphoprotein 2 (FOXM1, FKHL16, HFH11)

Function: - transcriptional activation - role in control of cell proliferation (putative) - hosphorylated in M phase (mitosis) Structure: - contains 1 fork-head DNA-binding domain - within the protein there is a domain which acts as a transcriptional activator Compartment: nucleus Alternative splicing: named isoforms=3 - isoforms 1 & 2 appear to be the only activatorsof gene transcription - isoform 3, found in rat, does not seem to exist in human Expression: - expressed in thymus, testis, small intestine,colon > ovary - expressed only in adult organs containing proliferating cells or in response to growth factors - expressed in epithelial cell lines derived from tumors - not expressed in resting cells - embryonic expression pattern: liver, lung, intestine, kidney, urinary tract - adult expression pattern: intestine, colon, testis, thymus - induced during liver regeneration & oxidative stress

General

forkhead family transcription factor M-phase phosphoprotein

Properties

SIZE: MW = 84 kD entity length = 763 aa COMPARTMENT: cell nucleus MOTIF: fork head domain NAME: fork head domain SITE: 235-327 threonine-rich region {480-513} MOTIF: threonine residue (SEVERAL) Thr phosphorylation site {T662} Ser phosphorylation site {S704}

Database Correlations

OMIM 602341 UniProt Q08050

References

UniProt :accession Q08050