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forkhead box protein K1; myocyte nuclear factor; MNF (FOXK1)
Function:
1) transcriptional regulator
2) binds to the upstream enhancer region (CCAC box) of myoglobin gene
3) role in myogenic differentiation & in remodeling processes of adult muscles that occur in response to physiological stimuli
4) interacts with SIN3B to form a complex which represses transcription
5) phosphorylated
Structure:
- contains 1 FHA domain
- contains 1 fork-head DNA-binding domain
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression: expressed both developing & adult tissues
Pathology:
- expressed in tumors of the brain, colon, lymph node
General
forkhead family transcription factor
phosphoprotein
Properties
SIZE: MW = 75 kD
entity length = 733 aa
COMPARTMENT: cell nucleus
MOTIF: alanine-rich region {10-96}
MOTIF: alanine residue (SEVERAL)
proline-rich region
SITE: 35-62
MOTIF: proline residue (SEVERAL)
forkhead-associated (FHA) domain {123-175}
fork head domain
NAME: fork head domain
SITE: 305-400
Database Correlations
UniProt P85037
PFAM correlations
Entrez Gene 221937
References
- Entrez Gene :accession P85037
- UniProt :accession P85037