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forkhead box protein J2; Fork head homologous X (FOXJ2, FHX)
Function:
- transcriptional activator
- able to bind to two different type of DNA binding sites
- isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure: contains 1 fork-head DNA-binding domain
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression: widely expressed
General
forkhead family transcription factor
phosphoprotein
zinc finger protein
Properties
SIZE: MW = 62 kD
entity length = 574 aa
COMPARTMENT: cell nucleus
MOTIF: fork head domain
NAME: fork head domain
SITE: 66-143
serine residue {266-270} (5)
Zinc finger
NAME: Zinc finger
EFFECTOR-BOUND: Zn+2
phosphorylation site
proline residue {295-298} (4)
proline residue {390-395} (6)
Database Correlations
UniProt Q9P0K8
Entrez Gene 55810
References
- UniProt :accession Q9P0K8
- Entrez Gene :accession 55810