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forkhead box protein I1; forkhead-related transcription factor 6; FREAC-6; drosophila forkhead homolog-like 10 (FREAC6, FOXI1)

Function: - transcriptional activator required for the development of normal hearing, sense of balance & kidney function - required for expression of SLC26A4/PDS, JAG1 & COCH in a subset of epithelial cells & the development of the endolymphatic system in the inner ear - required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 & the differentiation of intercalated cells in the epithelium of distal renal tubules Structure: contains 1 fork-head DNA-binding domain Compartment: nucleus Alternative splicing: named isoforms=2 Expression: expressed in kidney

General

forkhead family transcription factor

Properties

SIZE: MW = 41 kD entity length = 378 aa COMPARTMENT: cell nucleus MOTIF: proline-rich region SITE: 7-97 MOTIF: proline residue (SEVERAL) fork head domain NAME: fork head domain SITE: 123-217

Database Correlations

OMIM 601093 MORBIDMAP 601093 UniProt Q12951 Entrez Gene 2299

References

  1. Entrez Gene :accession 2299
  2. UniProt :accession Q12951