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forkhead box protein F2; forkhead-related transcription factor 2; FREAC-2; forkhead-related activator-2; drosophila forkhead homolog-like 6 (FOXF2)
Function:
- probable transcription activator for a number of lung-specific genes
- interacts with the transcription factors TBP & TFIIB
Compartment: nucleus
Expression: lung, placenta
Structure:
- contains 1 fork-head DNA-binding domain
- two activation domains, AD1 & AD2, C-terminal of (& distinct from) the forkhead domains are necessary for transcriptional activation
General
forkhead family transcription factor
Properties
SIZE: MW = 46 kD
entity length = 444 aa
COMPARTMENT: cell nucleus
MOTIF: alanine-rich region {33-41}
MOTIF: alanine residue (SEVERAL)
serine-rich region {46-55}
MOTIF: serine residue (SEVERAL)
serine-rich region {58-67}
MOTIF: serine residue (SEVERAL)
glycine-rich region {77-84}
fork head domain
NAME: fork head domain
SITE: 99-190
histidine-rich region {262-272}
MOTIF: histidine residue (SEVERAL)
glycine-rich region {301-306}
serine-rich region {312-315}
MOTIF: serine residue (SEVERAL)
histidine-rich region {429-432}
MOTIF: histidine residue (SEVERAL)
Database Correlations
OMIM 603250
UniProt Q12947
Entrez Gene 2295
References
- Entrez Gene :accession 2295
- UniProt :accession Q12947