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forkhead box protein D3; NF3/FH transcription factor genesis (FOXD3)
Function:
- binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3'
- acts as a transcriptional repressor
- also acts as a transcriptional activator
- promotes development of neural crest cells from neural tube progenitors
- restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation
- required for maintenance of pluripotent cells in pre-implantation & peri-implantation stages of embryogenesis
Structure: contains 1 fork-head DNA-binding domain
Compartment: nucleus
Expression:
- expressed in chronic myeloid leukemia, Jurkat T-cell leukemia & teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined
General
forkhead family transcription factor
Properties
SIZE: MW = 48 kD
entity length = 478 aa
COMPARTMENT: cell nucleus
MOTIF: fork head domain
NAME: fork head domain
SITE: 141-235
alanine-rich region {262-268}
MOTIF: alanine residue (SEVERAL)
alanine-rich region {280-285}
MOTIF: alanine residue (SEVERAL)
alanine-rich region {290-300}
MOTIF: alanine residue (SEVERAL)
alanine-rich region {350-355}
MOTIF: alanine residue (SEVERAL)
alanine-rich region {460-473}
MOTIF: alanine residue (SEVERAL)
Database Correlations
UniProt Q9UJU5
Entrez Gene 27022
References
- Entrez Gene :accession 27022
- UniProt :accession Q9UJU5