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forkhead box protein A1; hepatocyte nuclear factor 3-alpha; HNF-3A (FOXA1)
Function:
- transcription factor for liver genes, including albumin AFP, tyrosine aminotransferase, PEPCK
- interacts with cis-acting regulatory regions of these genes Strucuture: contains 1 fork-head DNA-binding domain
Compartment: nucleus
Expression:
- expressed in tissues of endodermal origin, i.e., stomach, intestines, liver, lung
Pathology:
- gene amplification in esophageal adenocarcinoma & lung cancer
General
forkhead family transcription factor
hepatocyte nuclear factor
phosphoprotein
Properties
SIZE: entity length = 473 aa
COMPARTMENT: cell nucleus
MOTIF: fork head domain
NAME: fork head domain
SITE: 170-261
Thr phosphorylation site {T344}
Database Correlations
OMIM 602294
UniProt P55317
Entrez Gene 3169
References
- Entrez Gene :accession 3169
- OMIM :accession 602294
- UniProt :accession P55317