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follistatin-related protein 1 (follistatin-like 1, FSTL1, FRP)
Function:
1) modulates action of some growth factors in cell proliferation & differentiation (putative)
2) binds heparin
3) interacts with SCN10A
4) role in embryonic development of the heart
5) continues to be produced in adulthood
Structure:
- contains 2 EF-hand domains
- contains 1 follistatin-like domain
- contains 1 Kazal-like domain
- contains 1 VWFC domain
Compartment: secreted
Expression:
- epicardium [2]
Pathology:
- after myocardial infarction, the epicardium stops producing FSTL1
- FSTL1 patches on the epicardial surface over an infarcted area of myocardium in mice or pigs resulted in regeneration of cardiomyocytes, increased vascularization, diminished scarring, improved contractility, & lengthened lifespan
General
Ca+2 binding protein
follistatin-related protein (follistatin-like protein)
secreted protein
Properties
SIZE: MW = 35 kD
entity length = 308 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
Follistatin-like {30-53}
Kazal-type serine protease inhibitor domain {54-98}
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+0}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+X2}
cysteine residue {C54}
MODIFICATION: cysteine residue {C84}
cysteine residue {C58}
MODIFICATION: cysteine residue {C77}
cysteine residue {C66}
MODIFICATION: cysteine residue {C98}
cysteine residue {C77}
MODIFICATION: cysteine residue {C58}
cysteine residue {C84}
MODIFICATION: cysteine residue {C54}
cysteine residue {C98}
MODIFICATION: cysteine residue {C66}
FOR-BINDING-OF: serine protease
EF hand
SITE: 144-178
MOTIF: N-glycosylation site {N144}
N-glycosylation site {N175}
N-glycosylation site {N180}
EF hand
SITE: 193-228
VWFC domain {233-287}
Database Correlations
OMIM 605547
UniProt Q12841
PFAM correlations
References
- UniProt :accession Q12841
- Wei K et al.
Epicardial FSTL1 reconstitution regenerates the adult mammalian
heart.
Nature 2015 Sep 24; 525:479.
PMID: 26375005
- Vunjak-Novakovic G.
Cardiac biology: A protein for healing infarcted hearts.
Nature 2015 Sep 24; 525:461
PMID: 26375007