folate receptor gamma; FR-gamma; folate receptor 3 (FOLR3)

Function: - binds to folate & reduced folic acid derivatives - mediates delivery of 5-methyltetrahydrofolate to the interior of cells - isoform short does not bind folate Structure: - 8 disulfide bonds are present (probable) - belongs to the folate receptor family Compartment: secreted Alternative splicing: named isoforms=2 Expression: - expressed in spleen, thymus, bone marrow, Pathology: - expressed in ovarian carcinoma, & uterine carcinoma Note: - may be produced at very low levels due to a premature stop odon in the mRNA, leading to nonsense-mediated mRNA decay

Properties

SIZE: entity length = 243 aa MW = 28 kD COMPARTMENT: plasma membrane CELL-REGION: apical region CELL: epithelial cell MOTIF: signal sequence {1-23} N-glycosylation site {N119} N-glycosylation site {N159} N-glycosylation site {N199}

Database Correlations

OMIM 602469 UniProt P41439 Pfam PF03024 Kegg hsa:2352

References

UniProt :accession P41439