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folate receptor 2; folate receptor beta; FR-beta; folate receptor, fetal/placental; placental folate-binding protein; FBP (FOLR2)
Function:
- binds to folate & reduced folic acid derivatives
- mediates delivery of 5-methyltetrahydrofolate to the interior of cells
- 8 disulfide bonds are present (probable)
Structure:
- N-glycosylated
- belongs to the folate receptor family
Compartment:
- cell membrane; lipid-anchor, GPI-anchor
- secreted (probable)
Expression:
- expressed in placenta & hematopoietic cells
- expression is increased in malignant tissues
General
folate receptor or folate-binding protein
Properties
SIZE: entity length = 255 aa
MW = 29 kD
COMPARTMENT: plasma membrane
CELL-REGION: apical region
CELL: epithelial cell
MOTIF: signal sequence {1-16}
N-glycosylation site {N115}
N-glycosylation site {N195}
glycosyl phosphatidylinositol [GPI] membrane anchor {N230}
Database Correlations
OMIM 136425
UniProt P14207
Pfam PF03024
Kegg hsa:2350
References
UniProt :accession P14207