Search
folate receptor alpha; FR-alpha; folate receptor 1; folate receptor, adult; adult folate-binding protein; FBP; ovarian tumor-associated antigen MOv18; KB cells FBP (FOLR1, FOLR)
Function:
- binds to folate & reduced folic acid derivatives
- mediates delivery of 5-methyltetrahydrofolate to the interior of cells
- secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, &/or by proteolysis catalyzed by a metalloprotease
Structure:
- belongs to the folate receptor family
- 8 disulfide bonds are present (probable)
Compartment:
- cell membrane; lipid-anchor, GPI-anchor
- secreted (probable)
Expression:
- exclusively expressed in tissues of epithelial origin
Pathology:
- expression is increased in malignant tissues
General
folate receptor or folate-binding protein
Properties
SIZE: entity length = 257 aa
MW = 30 kD
COMPARTMENT: plasma membrane
CELL-REGION: apical region
CELL: epithelial cell
MOTIF: signal sequence {1-24}
N-glycosylation site {N69}
N-glycosylation site {N161}
N-glycosylation site {N201}
glycosyl phosphatidylinositol [GPI] membrane anchor {N234}
Database Correlations
OMIM 136430
MORBIDMAP 136430
UniProt P15328
Pfam PF03024
Kegg hsa:2348
References
UniProt :accession P15328