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SL cytokine; Fms-related tyrosine kinase 3 ligand; Flt3 ligand; Flt3L (FLT3LG)
Function:
- stimulates the proliferation of early hematopoietic cells
- synergizes well with a number of other colony stimulating factors & interleukins
- homodimer (isoform 2)
Compartment:
- isoform 1: cell membrane; single-pass type 1 membrane protein
- isoform 2: secreted
Alternative splicing: named isoforms=2
General
membrane protein
oligomerizing protein
Properties
SIZE: entity length = 235 aa
MW = 26 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-26}
cysteine residue {C30}
MODIFICATION: cysteine residue {C111}
cysteine residue {C70}
MODIFICATION: cysteine residue {C153}
cysteine residue {C111}
MODIFICATION: cysteine residue {C30}
cysteine residue {C119}
MODIFICATION: cysteine residue {C158}
N-glycosylation site {N126}
N-glycosylation site {N149}
cysteine residue {C153}
MODIFICATION: cysteine residue {C70}
cysteine residue {C158}
MODIFICATION: cysteine residue {C119}
transmembrane domain {185-205}
Database Correlations
OMIM 600007
UniProt P49771
Pfam PF02947
Entrez Gene 2323
Kegg hsa:2323
References
UniProt :accession P49771