N-formyl peptide receptor 3; FMLP-related receptor II; FMLP-R-II; formyl peptide receptor-like 2 (FPR3, FPRH1, FPRL2)

Function: - low affinity receptor for N-formyl-methionyl peptides, (neutrophils chemotactic factors) - binding of FMLP to the receptor causes activation of neutrophils - response is mediated via a G-protein that activates a phosphatidylinositol-Ca⁺² second messenger system Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 353 aa MW = 40 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-27} MOTIF: N-glycosylation site {N4} N-glycosylation site {N10} transmembrane domain {28-50} cytoplasmic loop {51-61} transmembrane domain {62-83} exoplasmic loop {84-100} MOTIF: cysteine residue {C98} MODIFICATION: cysteine residue {C176} transmembrane domain {101-121} cytoplasmic loop {122-140} transmembrane domain {141-162} exoplasmic loop {163-205} MOTIF: cysteine residue {C176} MODIFICATION: cysteine residue {C98} transmembrane domain {206-226} cytoplasmic loop {227-242} transmembrane domain {243-266} exoplasmic loop {267-286} transmembrane domain {287-306} cytoplasmic domain {307-353}

Database Correlations

OMIM 136539 UniProt P25089 Pfam PF00001 Kegg hsa:2359

References

UniProt :accession P25089