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fMet-Leu-Phe receptor; fMLP receptor; N-formyl peptide receptor; FPR; N-formylpeptide chemoattractant receptor (FPR1)
Function:
- high affinity receptor for N-formyl-methionyl peptides, which are neutrophils chemotactic factors
- binding of FMLP to the receptor causes activation of neutrophils
- this response is mediated via a G-protein that activates a phosphatidylinositol-Ca+2 second messenger system
- phosphorylation is necessary for desensitization
Structure:
- belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane; multi-pass membrane protein
Expression: neutrophils
Related
N-formyl peptide receptor 2; FMLP-related receptor I; FMLP-R-I; formyl peptide receptor-like 1; lipoxin A4 receptor; LXA4 receptor; RFP; HM63 (FPR2 FPRH1 FPRL1 LXA4R)
N-formyl peptide receptor 3; FMLP-related receptor II; FMLP-R-II; formyl peptide receptor-like 2 (FPR3, FPRH1, FPRL2)
General
glycoprotein
phosphoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 350 aa
MW = 38 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-27}
MOTIF: N-glycosylation site {N4}
N-glycosylation site {N10}
transmembrane domain {28-50}
cytoplasmic loop {51-61}
transmembrane domain {62-83}
exoplasmic loop {84-100}
MOTIF: cysteine residue {C98}
MODIFICATION: cysteine residue {C176}
transmembrane domain {101-121}
cytoplasmic loop {122-140}
transmembrane domain {141-162}
exoplasmic loop {163-205}
MOTIF: cysteine residue {C176}
MODIFICATION: cysteine residue {C98}
transmembrane domain {206-226}
cytoplasmic loop {227-242}
transmembrane domain {243-266}
exoplasmic loop {267-285}
transmembrane domain {286-305}
cytoplasmic domain {306-350}
MOTIF: Ser phosphorylation site {S328}
Thr phosphorylation site {T329}
Thr phosphorylation site {T331}
Ser phosphorylation site {S332}
Thr phosphorylation site {T334}
Thr phosphorylation site {T336}
Ser phosphorylation site {S338}
Thr phosphorylation site {T339}
Database Correlations
OMIM 136537
UniProt P21462
Pfam PF00001
Entrez Gene 2357
Kegg hsa:2357
References
- UniProt :accession P21462
- Taga T & Kishimoto T
Cytokine receptors and signal transduction
FASEB J 6:3387 1992
PMID: 1334470