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fluorescein (Fluor-I-Strip, Fluress, Funduscein, AK-Fluor, Fluorescite, Ful-Glo)
Indications:
1) demonstration of defects in corneal epithelium
2) diagnostic aid in ophthalmic angiography
Dosage:
1) solution
a) 1-2 drop of 2% solution
b) allow to stand for a few seconds
c) wash out excess with irrigation solution
2) strips
a) moisten strip with sterile water
b) place strip at fornix into the lower cul-de-sac close to the punctum
3) injection
a) MUST perform intradermal skin test prior to use
b) usual dose: 500-750 mg in antecubital vein
Injection: 10% (5 mL), 25% (3 mL) Strip ophthalmic 1 mg (300s); 9 mg (300s) Solution ophthalmic: (Fluress) 0.25% with benoximate HCl 0.4% (5 mL)
Adverse effects:
1) not common (1-10%)
- temporary stinging, burning, irritation
2) uncommon (< 1%)
- severe shock, cardiac arrest, syncope, hypotension, basilar artery ischemia, thrombophlebitis, headache, nausea, GI distress, vomiting
3) other
- extravasation results in local tissue damage
- soft contact lenses will become discolored
- skin stains for about 6-12 hours
- urine stains for about 24-36 hours CAUTIONS:
1) do NOT replace contact lenses for at least 1 hours
2) flush out eye prior to replacement of contact lenses
Mechanism of action:
1) water-soluble dye
2) penetrate any break in epithelial barrier
General
carboxylate
heterocyclic compound, 3 rings
phenol
pigment
Properties
MISC-INFO: pregnancy-category X
Database Correlations
PUBCHEM cid=16850
References
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Department of Veterans Affairs, VA National Formulary
Component-of
fluorescein/proparacaine