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floxuridine; fluorodeoxyurine; 2'-Deoxy-5-fluorouridine
Indications:
- gastrointestinal cancer (adenocarcinoma) with liver metastases
Dosage:
- for intra-arterial infusion only
- 0.1 to 0.6 mg/kg/day
- doses of 0.4 to 0.6 mg for hepatic artery infusion
- reconstituted with 5 mL of sterile water for injection to yield a solution containing approximately 100 mg/mL of floxuridine
- the calculated daily dose(s) of the drug is then diluted with 5% dextrose or 0.9% sodium chloride injection to a volume appropriate for the infusion apparatus to be used
- therapy can be given until adverse reactions appear
Adverse effects:
- procedural complications of regional arterial infusion (most common) [1]
- common: [1] nausea, vomiting, diarrhea, enteritis, stomatitis, localized erythema
- common laboratory abnormalities:
- anemia, leukopenia, thrombocytopenia
- elevations of serum alkaline phosphatase, serum AST, serum ALT, serum bilirubin & serum lactic dehydrogenase
General
fluoropyrimidine
antineoplastic agent (chemotherapeutic agent)
Database Correlations
PUBCHEM correlations
References
- RxList
http://www.rxlist.com/floxuridine-drug.htm