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protein flightless-1 homolog (FLII, FLIL)
Function:
- may play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors
- acts in cooperation with NCOA2 & CARM1
- involved in estrogen hormone signaling
- involved in early embryonic development
- may play a role in regulation of cytoskeletal rearrangements involved in cytokinesis & cell migration
- interacts with actin, ACTL6A, NCOA2, CARM1, LRRFIP1 & LRRFIP2
- interacts with the nuclear receptors ESR1 & THRB
Structure:
- contains 5 gelsolin-like repeats
- contains 15 LRR repeats (leucine-rich repeats)
Compartment:
- nucleus (putative)
- cytoplasm, cytoskeleton (putative)
- centrosome (putative)
- colocalizes to actin-rich structures in blastocysts &, together with HRAS1, RHOA & CDC42, in migrating fibroblasts
Expression:
- strongest expression in skeletal muscle
- high expression in heart & lung
Pathology:
- deletion of the FLII gene may be a cause of Smith-Magenis syndrome
General
leucine-rich repeat-containing protein (LRRC)
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 1269 aa
MW = 145 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: LRRFIP1 and LRRFIP2 interaction {1-427}
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
leucine-rich repeat
SITE: 7-32
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 33-55
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 56-78
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 80-103
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 104-126
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 127-149
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 150-173
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 175-196
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 197-222
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 223-245
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 247-268
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 269-291
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 293-316
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 318-339
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 340-363
MOTIF: leucine residue (SEVERAL)
Ser phosphorylation site {S406}
alanine-rich region {411-415}
MOTIF: alanine residue (SEVERAL)
Ser phosphorylation site {S436}
ACTL6A interaction {495-827}
MOTIF: Gelsolin-like {501-559}
Gelsolin-like {640-670}
Gelsolin-like {755-798}
Ser phosphorylation site {S856}
glutamate-rich region {892-978}
MOTIF: glutamate residue (SEVERAL)
Gelsolin-like {1068-1115}
Gelsolin-like {1176-1218}
Database Correlations
OMIM correlations
UniProt Q13045
PFAM correlations
Entrez Gene 2314
Kegg hsa:2314
References
UniProt :accession Q13045