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FK506-binding protein 15 (FKBP15 KIAA0674)
Function:
- role in cytoskeletal organization of neuronal growth cones (putative)
- seems to be inactive as a PPIase
Structure:
- belongs to the FKBP-type PPIase family
- contains 1 PPIase FKBP-type domain, seems to be inactive both for FK506-binding & enzymatic activity
Compartment:
- cytoplasm, cell projection, axon (putative)
- present in axons & neuronal growth cones (putative)
Alternative splicing: named isoforms=3
General
cytoskeletal protein
phosphoprotein
Properties
SIZE: entity length = 1219 aa
MW = 134 kD
COMPARTMENT: cytoplasm
MOTIF: growth cone organization {72-169}
active site
SITE: 197-290
Ser phosphorylation site {S311}
coiled coil {522-789}
coiled coil {818-878}
coiled coil {925-951}
Ser phosphorylation site {S956}
Ser phosphorylation site {S1097}
Thr phosphorylation site {T1099}
Ser phosphorylation site {S1114}
Ser phosphorylation site {S1161}
Ser phosphorylation site {S1162}
Ser phosphorylation site {S1164}
Ser phosphorylation site {S1195}
Database Correlations
UniProt Q5T1M5
Pfam PF00254
References
UniProt :accession Q5T1M5