Fizzy-related protein homolog; Fzr; Cdh1/Hct1 homolog; hCDH1; CDC20-like protein 1 (FZR1, CDH1, FYR, FZR, KIAA1242)

Function: - regulates ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) & may confer substrate specificity upon the complex - the APC/C-Cdh1 dimeric complex is activated during anaphase & telophase & remains active in degrading substrates until onset of the next S phase - protein modification; protein ubiquitination - phosphorylated during mitosis, probably by maturation promoting factor (MPF) - the unphosphorylated form interacts with APC/C during mitosis - interacts with NINL Structure: - belongs to the WD repeat CDC20/Fizzy family - contains 7 WD repeats Compartment: - isoform 2: nucleus - isoform 3: cytoplasm Alternative splicing: named isoforms=3 Expression: - isoform 2 is expressed at high levels in heart, liver, spleen & some cancer cell lines - isoform 3 is expressed only at low levels in these tissues

General

phosphoprotein transcription factor (TF) WD repeat protein family

Properties

SIZE: entity length = 496 aa MW = 55 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: Thr phosphorylation site {T32} Ser phosphorylation site {S36} Ser phosphorylation site {S39} Ser phosphorylation site {S40} Tyr phosphorylation site {Y91} Ser phosphorylation site {S92} Ser phosphorylation site {S137} Ser phosphorylation site {S138} Ser phosphorylation site {S146} Ser phosphorylation site {S151} WD repeat {182-222} WD repeat {227-266} WD repeat {269-306} WD repeat {311-350} WD repeat {353-395} WD repeat {397-438} WD repeat {441-480}

Database Correlations

OMIM 603619 UniProt Q9UM11 Pfam PF00400 Entrez Gene 51343 Kegg hsa:51343

References

UniProt :accession Q9UM11