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filamin (actin-binding protein)
Function:
- cross-links actin filaments at high branch angles
- actin filaments tend to align spontaneously in bundles & a number of actin cross-linking proteins stabilize such bundles
- filamin, however, counter-acts the natural tendency of actin to form bundles orienting & cross-linking actin at high branch angles.
- the network of actin filaments formed by filamin cross-linking creates a cytoskeletal meshwork that excludes organelles (size exclusion), but allows perfusion of soluble proteins & small vesicles
Interactions
molecular events
Related
CD64; high affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc-gamma RI; FcRI (FCGR1A, FCG1, FCGR1, IGFR1)
Specific
filamin B (beta filamin, actin binding protein-278, thyroid autoantigen, truncated actin-binding protein, truncated ABP, ABP-280 homolog, ABP-278, filamin 3, filamin homolog 1, Fh1, FLNB, FLN1L, FLN3, TABP TAP)
filamin C; gamma filamin; filamin-2; actin binding protein-280 autosomal form; protein FLNc; actin-binding-like protein; ABP-L; ABP-280-like protein (FLNC, ABPL, FLN2)
Filamin-A; alpha-filamin; Filamin-1; endothelial actin-binding protein; actin-binding protein 280; ABP-280; non-muscle filamin (FLNA, FLN, FLN1)
General
cytoskeletal protein
oligomerizing protein
Properties
CONFIGURATION: dimer
SIZE: MW = 270 kD
COMPARTMENT: cytoplasm
MOTIF: binding site
FOR-BINDING-OF: high affinity immunoglobulin gamma Fc receptor I
binding site (2)
FOR-BINDING-OF: F-actin
References
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 889
- Stossel TP.
On the crawling of animal cells.
Science. 1993 May 21;260(5111):1086-94. Review.
PMID: 8493552