Search
fibronectin type III domain-containing protein 5 (fibronectin type III repeat-containing protein 2) (FNDC5 FRCP2)
Function:
- cleaved & secreted as the hormone, irisin
Structure: contains 1 fibronectin F3 module
Compartment:
- peroxisome membrane
- imported in peroxisomes through the PEX5 receptor pathway (putative)
Alternative splicing: named isoforms=4
Expression:
- expressed in skeletal muscle
- induced by PGC1-alpha
Specific
irisin
General
glycoprotein
hormone
membrane protein
secreted protein
Properties
SIZE: entity length = 196 aa
MW = 22 kD
COMPARTMENT: peroxisome
MOTIF: signal sequence {1-15}
fibronectin type III domain or F3 module {18-108}
MOTIF: N-glycosylation site {N23}
transmembrane domain {137-157}
microbody-targeting signal {194-196}
Database Correlations
UniProt Q8NAU1
Pfam PF00041
Kegg hsa:2529
References
UniProt :accession Q8NAU1