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fibromodulin; FM; collagen-binding 59 kD protein; keratan sulfate proteoglycan fibromodulin; KSPG fibromodulin (FMOD, FM, SLRR2E)

Function: - affects the rate of fibrils formation - may have a primary role in collagen fibrillogenesis (putative) - binds keratan sulfate chains - binds to type 1 collagen & type 2 collagen (putative) Structure: - belongs to the small leucine-rich proteoglycan (SLRP) family, class II subfamily contains 12 LRR repeats (leucine-rich repeats) Compartment: - secreted, extracellular space, extracellular matrix

General

matrix protein proteoglycan core protein

Properties

SIZE: entity length = 376 aa MW = 43 kD COMPARTMENT: extracellular matrix MOTIF: signal sequence {1-18} tyrosine residue {63} tyrosine residue {65} cysteine-rich region {76-92} leucine-rich repeat SITE: 98-117 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 118-141 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N127} leucine-rich repeat SITE: 142-167 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N166} leucine-rich repeat SITE: 168-188 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 189-212 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N201} leucine-rich repeat SITE: 213-235 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 236-256 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 257-280 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 281-305 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N291} leucine-rich repeat SITE: 306-325 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 326-355 MOTIF: leucine residue (SEVERAL) cysteine residue {C334} MODIFICATION: cysteine residue {C367} N-glycosylation site {N341} leucine-rich repeat SITE: 356-376 MOTIF: leucine residue (SEVERAL) cysteine residue {C367} MODIFICATION: cysteine residue {C334}

Database Correlations

OMIM 600245 UniProt Q06828 PFAM correlations Entrez Gene 2331

References

  1. UniProt :accession Q06828
  2. Ruoslahti E, Yamaguchi Y. Proteoglycans as modulators of growth factor activities. Cell. 1991 Mar 8;64(5):867-9. Review. PMID: 2001586