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fibroleukin; fibrinogen-like protein 2; pT49 (FGL2)
Function:
- may play a role in physiologic lymphocyte functions at mucosal sites
- homotetramer; disulfide-linked
Structure: contains 1 fibrinogen C-terminal domain
Compartment: secreted
Expression: constitutively expressed in cytotoxic T-cells
Related
fibrinogen; coagulation factor-1
General
glycoprotein
oligomerizing protein
secreted protein
Properties
SIZE: entity length = 439 aa
MW = 50 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-23}
N-glycosylation site {N25}
coiled coil {73-165}
N-glycosylation site {N179}
Fibrinogen C-terminal {204-436}
MOTIF: cysteine residue {C213}
MODIFICATION: cysteine residue {C242}
N-glycosylation site {N235}
cysteine residue {C242}
MODIFICATION: cysteine residue {C213}
N-glycosylation site {N263}
N-glycosylation site {N336}
cysteine residue {C371}
MODIFICATION: cysteine residue {C384}
cysteine residue {C384}
MODIFICATION: cysteine residue {C371}
Database Correlations
OMIM 605351
UniProt Q14314
Pfam PF00147
Entrez Gene 10875
Kegg hsa:10875
References
- UniProt :accession Q14314
- SeattleSNPs
http://pga.gs.washington.edu/data/fgl2/