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fibroblast growth factor receptor substrate 3; FGFR substrate 3; Suc1-associated neurotrophic factor target 2; SNT-2; FGFR signalling adaptor SNT2 (FRS3)
Function:
1) adapter protein that links FGR & NGF receptors to downstream signaling pathways
2) activation of MAP kinases
3) down-regulates ERK2 signaling by interfering with phosphorylation & nuclear translocation of ERK2
4) phosphorylated on Tyr upon stimulation by BFGF or NGFB
5) phosphorylated by ULK2 in vitro
6) binds NTRK1, FGFR1, NGFR, GRB2, PTPN11, ERK2
Structure: contains 1 IRS-type PTB domain
Compartment: membrane, lipid-anchor
Related
fibroblast growth factor
fibroblast growth factor receptor substrate
fibroblast growth factor [FGF] receptor
General
myristoylated protein
receptor
Properties
SIZE: entity length = 492 aa
MW = 54 kD
COMPARTMENT: cellular membrane
MOTIF: myristoylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: myristate
myristoylation site
SITE: G2
EFFECTOR-BOUND: myristate
phosphotyrosine interaction domain
NAME: phosphotyrosine interaction domain
SITE: 13-115
ligand-binding site
Database Correlations
OMIM 607744
UniProt O43559
Pfam PF02174
Entrez Gene 10817
Kegg hsa:10817
References
UniProt :accession O43559