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fibrinogen concentrate/thrombin; fibrin sealant (Raplixa)
Indications:
- control surgical bleeding in patients for whom standard techniques (sutures) are insufficient
Dosage:
- spray-dried fibrin sealant
- should be used with an absorbable gelatin sponge
Adverse effects:
- constipation
- fever
- hypotension
- nausea
- surgical pain
Mechanism of action:
- contains fibrinogen & thrombin
- promotes clotting when dissolved in blood.
Related
fibrin
General
pharmacologic combination
hematologic agent
References
- FDA News Release. April 30, 2015
FDA approves Raplixa to help control bleeding during surgery.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm445247.htm
Components
fibrinogen; coagulation factor-1
thrombin; coagulation factor IIa