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FH1/FH2 domain-containing protein 3 (formin homolog overexpressed in spleen 2, hFHOS2, formactin-2, FHOD3, FHOS2, KIAA1695)
Function:
- actin-organizing protein
- may cause stress fiber formation together with cell elongation
- interacts with nestin/NES-based interfilament
Structure:
- belongs to the formin homology family
- contains 1 DAD domain (diaphanous autoregulatory domain)
- contains 1 FH1 domain (formin homology 1 domain)
- contains 1 FH2 domain (formin homology 2 domain)
- contains 1 GBD/FH3 domain (Rho GTPase-binding/formin homology 3 domain)
Compartment:
- cytoplasm, cytoskeleton
- main part of protein localizes to actin fibers
- remaining part displays filamentous staining
Alternative splicing: named isoforms=2
Expression: expressed in the heart, kidney & brain
General
cytoskeletal protein
Properties
SIZE: MW = 159 kD
entity length = 1422 aa
COMPARTMENT: cytoplasm
MOTIF: GBD/FH3 {18-411}
coiled coil {448-480}
serine-rich region {626-635}
MOTIF: serine residue (SEVERAL)
proline-rich region
SITE: 827-872
MOTIF: proline residue (SEVERAL)
FH1 {827-858}
FH2 {880-1316}
MOTIF: lysine-rich region {889-892}
MOTIF: lysine residue (SEVERAL)
DAD {1359-1391}
Database Correlations
UniProt Q2V2M9
Pfam PF02181
References
UniProt :accession Q2V2M9