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fibroblast growth factor receptor-like 1; FGF receptor-like protein 1; fibroblast growth factor receptor 5; FGFR-like protein; FGF homologous factor receptor (FGFRL1, FGFR5, FHFR, UNQ480/PRO943)
Function:
1) negative effect on cell proliferation
2) interacts with FGF2 with a low affinity
Structure:
- contains 3 Ig-like C2-type domain (immunoglobulin-like)
Compartment:
- plasma membrane (majority), Golgi, secretory vesicles
Expression:
- expressed preferentially in cartilagenous tissues & pancreas
- highly expressed in the liver, kidney, heart, brain & skeletal muscle
- weakly expressed in the lung, small intestine & spleen
General
fibroblast growth factor [FGF] receptor
glycoprotein
Properties
SIZE: entity length = 504 aa
MW = 55 kD
COMPARTMENT: golgi
STATE: active state
MOTIF: signal sequence {1-24}
immunoglobulin superfamily domain {29-115}
MOTIF: cysteine residue {C51}
MODIFICATION: cysteine residue {C99}
cysteine residue {C99}
MODIFICATION: cysteine residue {C51}
N-glycosylation site {N111}
immunoglobulin superfamily domain {147-237}
MOTIF: cysteine residue {C172}
MODIFICATION: cysteine residue {C221}
cysteine residue {C221}
MODIFICATION: cysteine residue {C172}
N-glycosylation site {N231}
immunoglobulin superfamily domain {246-354}
MOTIF: N-glycosylation site {N255}
cysteine residue {C268}
MODIFICATION: cysteine residue {C338}
N-glycosylation site {N293}
cysteine residue {C338}
MODIFICATION: cysteine residue {C268}
transmembrane domain {379-399}
histidine-rich region {479-501}
MOTIF: histidine residue (SEVERAL)
Database Correlations
OMIM 605830
UniProt Q8N441
PFAM correlations
KEGG correlations
References
UniProt :accession Q8N441