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fibroblast growth factor [FGF] receptor

Interactions

molecular events

Related

fibroblast growth factor

Specific

basic fibroblast growth factor receptor 1; FGFR-1; bFGF-R; Fms-like tyrosine kinase 2; c-fgr; CD331 (FGFR1, FGFBR, FLG, FLT2) fibroblast growth factor flg-2 fibroblast growth factor receptor 2; FGFR-2; keratinocyte growth factor receptor 2; CD332 (FGFR2, BEK, KGFR, KSAM) fibroblast growth factor receptor 3; FGFR-3; CD333 (FGFR3, JTK4) fibroblast growth factor receptor 4; FGFR-4; CD334 (FGFR4, JTK2, TKF) fibroblast growth factor receptor-like 1; FGF receptor-like protein 1; fibroblast growth factor receptor 5; FGFR-like protein; FGF homologous factor receptor (FGFRL1, FGFR5, FHFR, UNQ480/PRO943)

General

oligomerizing protein proto oncogene protein tyrosine kinase receptor (RTK)

Properties

COMPARTMENT: plasma membrane STATE: active state MOTIF: ligand-binding site immunoglobulin superfamily domain (3) N-glycosylation site transmembrane domain Tyr phosphorylation site kinase domain SITE: KD1 MOTIF: ATP-binding site NAME: ATP-binding site kinase domain SITE: KD2 MOTIF: ATP-binding site NAME: ATP-binding site

References

  1. Nisheke et al Proc Natl Acad Sci USA 87(1):424 1990
  2. Cross M, Dexter TM. Growth factors in development, transformation, and tumorigenesis. Cell. 1991 Jan 25;64(2):271-80. Review. PMID: 1988148
  3. Partanen J et al FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern. EMBO J. 1991 Jun;10(6):1347-54. PMID: 1709094