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fibroblast growth factor 8; FGF-8; androgen-induced growth factor; AIGF; heparin-binding growth factor 8; HBGF-8 (FGF8, AIGF)
Function:
- role in the regulation of embryonic development, cell proliferation, cell differentiation & cell migration
- required for normal brain, eye, ear & limb development during embryogenesis
- required for normal development of the GnRH neuronal system
- interacts with FGFR1, FGFR2, FGFR3 & FGFR4
- affinity between fibroblast growth factors (FGFs) & their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors
Structure:
- monomer, homodimer
- belongs to the heparin-binding growth factors family
Compartment: secreted
Alternative splicing:
- named isoforms=4
- additional isoforms seem to exist
Expression:
- in adults, expression is restricted to the gonads
Pathology:
- defects in FGF8 are the cause of Kallmann syndrome type 6
- defects in FGF8 are a cause of hypogonadotropic hypogonadism
General
fibroblast growth factor
glycoprotein
Properties
SIZE: entity length = 233 aa
MW = 27 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-22}
N-glycosylation site {N155}
SECRETED-BY: endothelial cell
Database Correlations
OMIM correlations
UniProt P55075
Pfam PF00167
Entrez Gene 2253
Kegg hsa:2253
References
- UniProt :accession P55075
- NIEHS-SNPs
http://egp.gs.washington.edu/data/fgf8/