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fibroblast growth factor 7; FGF-7; heparin-binding growth factor 7; HBGF-7; keratinocyte growth factor (FGF7 KGF)
Function:
- role in the regulation of embryonic development, cell proliferation & cell differentiation
- required for normal branching morphogenesis
- growth factor active on keratinocytes
- possible major paracrine effector of normal epithelial cell proliferation
- interacts with FGFBP1
- interacts with FGFR2
- affinity between fibroblast growth factors (FGFs) & their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors
Structure:
- belongs to the heparin-binding growth factors family
Compartment: secreted
Expression: epithelial cell
Specific
palifermin (Kepivance)
General
fibroblast growth factor
glycoprotein
Properties
SIZE: entity length = 194 aa
MW = 23 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-31}
N-glycosylation site {N45}
SECRETED-BY: macrophage
Database Correlations
OMIM 148180
UniProt P21781
Pfam PF00167
Entrez Gene 2252
Kegg hsa:2252
References
- UniProt :accession P21781
- Henderson B & Blake S
Therapeutic potential of cytokine manipulation
TIPS 13:145 1992
PMID: 1589908
- Entrez Gene :accession 2252