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fibroblast growth factor 6; FGF-6; heparin secretory-transforming protein 2; HST-2; HSTF-2; heparin-binding growth factor 6; HBGF-6 (FGF6, HST2, HSTF2)
Function:
- role in the regulation of cell proliferation, cell differentiation, angiogenesis & myogenesis, & is required for normal muscle regeneration
- interacts with FGFR1, FGFR2 & FGFR4
- affinity between fibroblast growth factors (FGFs) & their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors
Structure:
- belongs to the heparin-binding growth factors family
Compartment: secreted, extracellular space
Expression:
- leukemia cell lines with platelet/megakaryocytic differentiation potential
Genetics:
- product of hst2 (human) oncogene.
General
fibroblast growth factor
glycoprotein
proto oncogene protein
Properties
SIZE: entity length = 208 aa
MW = 23 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-37}
N-glycosylation site {N45}
cysteine residue {C90}
MODIFICATION: cysteine residue {C157}
cysteine residue {C157}
MODIFICATION: cysteine residue {C90}
SECRETED-BY: endothelial cell
Database Correlations
OMIM 134921
UniProt P10767
Pfam PF00167
Entrez Gene 2251
Kegg hsa:2251
References
- UniProt :accession P10767
- NIEHS-SNPs
http://egp.gs.washington.edu/data/fgf6/