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fibroblast growth factor 5; FGF-5; heparin-binding growth factor 5; HBGF-5; smag-82 (FGF5)
Function:
- role in the regulation of cell proliferation & cell differentiation
- required for normal regulation of the hair growth cycle
- inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (putative)
- interacts with FGFR1 & FGFR2
- affinity between fibroblast growth factors (FGFs) & their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors
Structure:
- belongs to the heparin-binding growth factors family
Compartment: secreted (putative)
Alternative splicing:
- named isoforms=2; long, short
- short isoform seems to have an antagonistic effect compared to that of long isoform
Expression:
- expressed in neonatal brain
Pathology:
- can transform NIH 3T3 cells
General
fibroblast growth factor
glycoprotein
proto oncogene protein
Properties
SIZE: entity length = 268 aa
MW = 30 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-17}
serine-rich region {49-52}
MOTIF: serine residue (SEVERAL)
serine-rich region {55-62}
MOTIF: serine residue (SEVERAL)
N-glycosylation site {N110}
SECRETED-BY: endothelial cell
Database Correlations
OMIM 165190
UniProt P12034
Pfam PF00167
Entrez Gene 2250
Kegg hsa:2250
References
- UniProt :accession P12034
- NIEHS-SNPs
http://egp.gs.washington.edu/data/fgf5/
- Entrez Gene :accession 2250