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fibroblast growth factor 4; FGF-4; heparin secretory-transforming protein 1; HST; HST-1; HSTF-1; heparin-binding growth factor 4; HBGF-4; transforming protein KS3 (FGF4, HST, HSTF1, KS3)
Function:
- role in the regulation of embryonic development, cell proliferation, & cell differentiation
- required for normal limb & cardiac valve development during embryogenesis
- interacts with FGFR1, FGFR2, FGFR3 & FGFR4
- affinity between fibroblast growth factors (FGFs) & their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors
Structure:
- belongs to the heparin-binding growth factors family
Compartment: secreted (putative)
Genetics:
- product of hst1 (human) or ks3 (mouse) proto-oncogene
Related
hst proto-oncogene; ks3 proto-oncogene
General
fibroblast growth factor
glycoprotein
proto oncogene protein
Properties
SIZE: entity length = 206 aa
MW = 22 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-30}
SECRETED-BY: endothelial cell
Database Correlations
OMIM 164980
UniProt P08620
Pfam PF00167
Entrez Gene 2249
Kegg hsa:2249
References
- UniProt :accession P08620
- Cross M, Dexter TM.
Growth factors in development, transformation, and tumorigenesis.
Cell. 1991 Jan 25;64(2):271-80. Review.
PMID: 1988148
- Entrez Gene :accession 2249