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fibroblast growth factor 3; FGF-3; heparin-binding growth factor 3; HBGF-3; proto-oncogene protein int-2 (FGF3, INT2)
Function:
- role in the regulation of embryonic development, cell proliferation, & cell differentiation
- required for normal ear development
- interacts with FGFR1 & FGFR2
- affinity between fibroblast growth factors (FGFs) & their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors
Structure:
- belongs to the heparin-binding growth factors family
Compartment: secreted (putative)
Pathology:
- defects in FGF3 are a cause of deafness with labyrinthine aplasia, microtia & microdontia
Genetics:
- product of int-2 proto-oncogene [1]
- FGF-3 is suggested to be a viral integration product [2]
Related
int2 proto-oncogene
General
fibroblast growth factor
glycoprotein
proto oncogene protein
Properties
SIZE: entity length = 239 aa
MW = 27 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-17}
N-glycosylation site {N65}
SECRETED-BY: endothelial cell
Database Correlations
OMIM correlations
UniProt P11487
Pfam PF00167
Entrez Gene 2248
Kegg hsa:2248
References
- Cross M, Dexter TM.
Growth factors in development, transformation, and tumorigenesis.
Cell. 1991 Jan 25;64(2):271-80. Review.
PMID: 1988148
- Entrez Gene :accession 2248
- UniProt :accession P11487