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fibroblast growth factor 18; FGF-18; zFGF5 (FGF18)
Function:
- role in regulation of cell proliferation, cell differentiation & cell migration
- required for normal ossification & bone development
- stimulates hepatic & intestinal proliferation
- interacts with FGFR3 & FGFR4
Structure:
- belongs to the heparin-binding growth factors family
Compartment: secreted (putative)
General
fibroblast growth factor
glycoprotein
Properties
SIZE: entity length = 207 aa
MW = 24 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-27}
N-glycosylation site {N39}
cysteine residue {C109}
MODIFICATION: cysteine residue {C127}
cysteine residue {C127}
MODIFICATION: cysteine residue {C109}
N-glycosylation site {N137}
SECRETED-BY: endothelial cell
Database Correlations
OMIM 603726
UniProt O76093
Pfam PF00167
Entrez Gene 8817
Kegg hsa:8817
References
- UniProt :accession O76093
- Entrez Gene :accession 8817