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fibroblast growth factor 17; FGF-17 (FGF17)
Function:
- role in regulation of embryonic development & as signaling molecule in the induction & patterning of the embryonic brain
- required for normal brain development
- interacts with FGFR3 & FGFR4
Structure:
- belongs to the heparin-binding growth factors family
Compartment: secreted
Alternative splicing: named isoforms=2
Expression:
- preferentially expressed in the embryonic brain
- detected in embryos at E14.5
- not detected at E10.5 & E19.5
- preferentially expressed in the neuroepithelia of the isthmus & septum of the embryonic brain at E14.5
General
fibroblast growth factor
glycoprotein
Properties
SIZE: entity length = 216 aa
MW = 25 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-22}
N-glycosylation site {N137}
SECRETED-BY: endothelial cell
Database Correlations
OMIM 603725
UniProt O60258
Pfam PF00167
Entrez Gene 8822
Kegg hsa:8822
References
- UniProt :accession O60258
- NIEHS-SNPs
http://egp.gs.washington.edu/data/fgf17/