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fibroblast growth factor 12; FGF-12; fibroblast growth factor homologous factor 1; FHF-1; myocyte-activating factor (FGF12, FGF12B, FHF1)
Function:
- probably involved in nervous system development & function
- interacts with the C-terminal region of SCN9A
Structure:
- belongs to the heparin-binding growth factors family
Compartment: nucleus (probable)
Alternative splicing: named isoforms=2
Expression:
- expressed in brain, eye & testis
- highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, & in a segmental pattern of the body wall
- expressed in adult olfactory bulb > cerebellum, deep cerebellar nuclei, cerebellar cortex & multiple midbrain structures
General
fibroblast growth factor
nuclear protein
Properties
SIZE: entity length = 243 aa
MW = 27 kD
COMPARTMENT: cell nucleus
MOTIF: nuclear translocation signal {11-38}
SECRETED-BY: endothelial cell
Database Correlations
OMIM 601513
UniProt P61328
Pfam PF00167
Entrez Gene 2257
Kegg hsa:2257
References
- UniProt :accession P61328
- Entrez Gene :accession 2257